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An estimated 1 million people worldwide die by suicide every year. Globally, suicide ranks among the three leading causes of death among those aged 15–44 years. Attempted suicides are up to 20 times more frequent than completed ones.
Incidence of suicide in a society depends on a range of factors. Clinical depression is an especially common cause. Bullying can also drive people to suicide, as it increases social isolation. Substance abuse and severe physical disease or infirmity are also recognized as causes. The Eastern Europe and East Asia regions have the highest suicide rate worldwide. The region with the lowest suicide rate is the Caribbean, followed by the Middle East.
Differences in suicide rates between genders are prominent, with males dying by suicide at a higher rate in almost every country in the world. However, females of all age groups tend to show higher rates of reported nonfatal suicidal behaviors.